| Identification | Back Directory | [Name]
2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE | [CAS]
60762-57-4 | [Synonyms]
Pirlindol
Pyrazidol
Pirlindole
Pirlindolum
Unii-V39yph45fz
PIRLINDOLE MESYLATE
Pirlindole free base
Pirlindolum [inn-latin]
16154-78-2 (Hydrochloride)
Pirlindol [inn-spanish, french]
2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole
8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole
1H-Pyrazino[3,2,1-jk]carbazole,2,3,3a,4,5,6-hexahydro-8-methyl-
2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE
8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino-[3,2,1-jk]carbazole methanesulfonate | [Molecular Formula]
C15H18N2 | [MDL Number]
MFCD00407230 | [MOL File]
60762-57-4.mol | [Molecular Weight]
226.32 |
| Hazard Information | Back Directory | [Description]
Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively). It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 μM independent of MAO-A activity. | [Uses]
Antidepressive;Monoamine oxidase inhibitor | [Biological Activity]
A highly selective reversible inhibitor of monoamine oxidase type A. | [storage]
Store at -20°C |
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