| Identification | Back Directory | [Name]
LECIRELIN | [CAS]
61012-19-9 | [Synonyms]
LECIRELIN
Supergestran
Lecirelin, BR
SUPERGESTRAN(TM)
Lecirelin Acetate
DalMarelin Acetate
(D-TLE6)-LEUPROLIDE
LECIRELIN USP/EP/BP
(D-TLE6)-LEUPRORELIN
[D-TLE6,PRO-NHET9]-LHRH
LECIRELIN (DALMARELIN) ACETATE
Lecirelin (Dalmarelin) Acetate
(DES-GLY10,TBU-D-GLY6,PRO-NHET9)-LHRH
GLP-HIS-TRP-SER-TYR-TLE-LEU-ARG-PRO-NHET
PYR-HIS-TRP-SER-TYR-TBU-D-GLY-LEU-ARG-PRO-NHET
(D-Tle6)-Leuprolide, (D-Tle6)-Leuprorelin, Lecirelin
Lecirelin, (D-Tle6)-Leuprolide, (D-Tle6)-Leuprorelin, DalMarelin
Lecirelin(6-(3-methyl-D-valine)-9-(N-ethyl-L-prolynamide)-10-deglycinamide)
(Des-Gly10,tBu-D-Gly6,Pro-NHEt9)-LHRH
(D-Tle6)-Leuprolide, (D-Tle6)-Leuprorelin, Lecirelin
1-9-LuteinizinghorMone-releasing factor (swine),6-(3-Methyl-D-valine)-9-(N-ethyl-L-prolinaMide)-
6-(3-Methyl-D-valine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing hormone-releasing factor (pig)
(Des-Gly10, tBu-D-Gly6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-tBu-D-Gly-Leu-Arg-Pro-NHEt acetate salt
(Des-Gly10, tBu-D-Gly6,Pro-NHEt 9)-LHRH trifluoroacetate salt Pyr-His-Trp-Ser-Tyr-tBu-D-Gly-Leu-Arg-Pro-NHEt trifluoroacetate salt | [EINECS(EC#)]
200-001-8 | [Molecular Formula]
C59H84N16O12 | [MDL Number]
MFCD00882473 | [MOL File]
61012-19-9.mol | [Molecular Weight]
1209.4 |
| Chemical Properties | Back Directory | [density ]
1.44 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 12.1 mg/mL (10.00 mM) | [form ]
Solid | [pka]
9.82±0.15(Predicted) | [color ]
White to off-white | [InChIKey]
XJWIEWPGHRSZJM-JUAATNMYNA-N |
| Hazard Information | Back Directory | [Uses]
Mammalian LHRHa containing Supergestran was used to stimulate the spermiation of tench males. Half dose of lecirelin was almost equally effective to induce the disappearance of the dominant follicle at Day 6 to 7 of the estrous cycle in three GnRH analogs of cattle. | [Definition]
Lecirelin, a synthetic gonadotropin-releasing hormone (GnRH) analog, acts as a GnRH agonist. Lecirelin is widely used for the research of bovine ovarian follicular cysts. lecithin and buserelin, two nonapeptides, are used as the acetate. Lecirelin differs by substitution of D-tertiary leucine for glycine at position 6 and the replacement of glycine by ethylamide at position 10. Buserelin has a D-serine at position 6 and ethylamide at position 10. | [in vitro]
Lecirelin (2.07 μM) significantly increases the tension and frequency of contractions in preovulatory follicles (PF), small follicular cysts (FC-S), and large follicular cysts (FC-L).
Lecirelin increases the strips from preovulatory follicles contract significantly more than strips from cysts. | [storage]
Store at -20°C | [References]
[1] Picard-Hagen N, et al. Effect of gonadorelin, lecirelin, and buserelin on LH surge, ovulation, and progesterone in cattle. Theriogenology, 2015; 84: 177-183. |
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