| Identification | Back Directory | [Name]
trilobine | [CAS]
6138-73-4 | [Synonyms]
trilobine
(1'β)-6',7-Oxy-6,12'-dimethoxy-2'-methyloxyacanthan
(1'α)-6',7-Epoxy-6,12'-dimethoxy-2'-methyloxyacanthan
2H-22,26-Epoxy-1,24:12,15-dietheno-6,10-metheno-16H-pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-9,21-dimethoxy-4-methyl-, (4aS,16aS)- | [Molecular Formula]
C35H34N2O5 | [MOL File]
6138-73-4.mol | [Molecular Weight]
562.67 |
| Hazard Information | Back Directory | [Description]
A bisbenzylisoquinoline alkaloid, this base has been isolated from Cocculus
sarmentosus Diels and C. trilobus DC. It crystallizes as colourless prisms and is
dextrorotatory with [α]29D + 296.3° (CHCI3). Both the hydrochloride and hydro_x0002_bromide are crystalline and sparingly soluble in H20 and the dimethiodide has
m.p. 273°C (dec.). Two methoxyl groups and two methylimino groups are
present. With dimethyl sulphate in NaOH, the base yields trilobinemethylmethine
as long, colourless prisms, m.p. 106° C which is optically inactive and on ozonization furnishes 2-methoxy-5:4'-dialdehydodiphenyl ether, m.p. 72-5°C and a
complex dialdehyde, m.p. 124°C. | [Definition]
ChEBI: Trilobine is a member of isoquinolines. | [References]
Kondo, Tomita., J. Pharm. Soc., Japan, 47, 39 (1927)
Kondo, Tomita., ibid, 48, 83 (1928)
Kondo, Tomita., ibid, SO, 91 (1930)
Faltis., Annalen, 497,69 (1932)
Kondo, Tomita., Arch. Pharm., 274, 65 (1936)
Faltis et al., Ber., 74,79 (1941) |
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