| Identification | Back Directory | [Name]
Azanidazole | [CAS]
62973-76-6 | [Synonyms]
Azanidazole
2-Pyrimidinamine, 4-[(1E)-2-(1-methyl-5-nitro-1H-imidazol-2-yl)ethenyl]- | [Molecular Formula]
C10H10N6O2 | [MOL File]
62973-76-6.mol | [Molecular Weight]
246.23 |
| Chemical Properties | Back Directory | [Melting point ]
232-235° | [Boiling point ]
389.22°C (rough estimate) | [density ]
1.3200 (rough estimate) | [refractive index ]
1.7000 (estimate) |
| Hazard Information | Back Directory | [Originator]
Triclose,Ist. Chemioter.,Italy,1977 | [Uses]
Antiprotozoal. | [Definition]
ChEBI: Azanidazole is a member of imidazoles and a C-nitro compound. | [Manufacturing Process]
Into a mixture of 1.6 g of 2-amino-4-methylpyrimidine with 10 ml of glacial
acetic acid is slowly added 2.13 g of concentrated sulfuric acid. A mixture of
2.4 g of 2-formyl-1-methyl-5-nitroimidazole in 20 ml of glacial acetic acid is
slowly added to the mixture of the pyrimidine under stirring. The reaction mixture is maintained at a temperature of about 55°C for 4 hours. The
resultant mixture is then diluted with 200 ml of distilled water and neutralized
with a saturated aqueous solution of sodium bicarbonate. A brownish-yellow
precipitate (MP 232° to 235°C) is formed and recovered. The product is
analyzed by infrared spectroscopy and is found to conform to 2-amino-4-[2-
(1-methyl-5-nitro-2-imidazolyl)vinyl]pyrimidine. | [Therapeutic Function]
Antiprotozoal, Antibacterial | [Safety Profile]
Moderately toxic byintraperitoneal route. Mildly toxic by ingestion.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits toxicfumes of NOx. |
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