| Identification | Back Directory | [Name]
thonzylamine hydrochloride | [CAS]
63-56-9 | [Synonyms]
NH 188
Anahist
Resistab
Thonzylamine HCl 98%
Neohetramine hydrochloride
thonzylamine hydrochloride
Thonzilamine hydrochloride
N-(4-Methoxybenzyl)-N-(2-(diMethylaMino)ethyl)pyriMidin-2-aMine
N-p-Methoxybenzyl-N',N'-dimethyl-N-2-pyrimidinylethylene diamine hydrochloride
1,2-Ethanediamine, N-(4-methoxyphenyl)methyl-N,N-dimethyl-N-2-pyrimidinyl-, monohydrochloride | [EINECS(EC#)]
200-561-3 | [Molecular Formula]
C16H22N4O.ClH | [MDL Number]
MFCD00058195 | [MOL File]
63-56-9.mol | [Molecular Weight]
322.84 |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
173-176° | [Boiling point ]
bp2.2 185-187° | [density ]
1.2562 (rough estimate) | [refractive index ]
1.5800 (estimate) | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Uses]
Medicine (antihistamine). | [EPA Substance Registry System]
Thonzylamine hydrochloride (63-56-9) |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [General Description]
White crystalline powder with a faint odor . pH: 5.1-5.7 (2 % aqueous solution). | [Air & Water Reactions]
Water soluble. | [Reactivity Profile]
thonzylamine hydrochloride behaves as a weak organic acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. | [Health Hazard]
SYMPTOMS: Symptoms of exposure to thonzylamine hydrochloride may include drowsiness, lethargy, fatigue, hypnosis, coma, vertigo, ataxia, tinnitus, blurred vision, tremors, anxiety, insomnia, excitement, hallucinations, delirium, convulsions, dry mouth, anorexia, nausea, vomiting, abdominal distress, constipation, diarrhea, central nervous system depression, gastrointestinal reactions, respiratory arrest and circulatory collapse. | [Fire Hazard]
Flash point data for thonzylamine hydrochloride are not available. thonzylamine hydrochloride is probably combustible. | [Originator]
Neohetramine,Warner Lambert,US,1948 | [Definition]
ChEBI: Thonzylamine hydrochloride is a member of methoxybenzenes. | [Manufacturing Process]
54 g of 2-(p-methoxybenzyl)aminopyrimidine and 12.0 g of sodamide were
suspended in 250 cc of toluene and were refluxed for 31 hours. To the thus
prepared sodium salt of 2-(p-methoxybenzyl)aminopyrimidine, 28.1 g of
dimethylaminoethyl chloride were added and refluxed under continuous
stirring for 26 hours. After cooling, the reaction mixture was extracted with
dilute hydrochloric acid at about pH 5.0, removing the product thus formed
containing only very little of the unreacted 2-(p_x0002_methoxybenzyl)aminopyrimidine. This solution was then made alkaline to
liberate the free base of the product, which was extracted with ether. The
ether solution was evaporated and the residue vacuum distilled. The product,
2-(p-methoxybenzyl-dimethylaminoethyl)aminopyrimidine forms an oily liquid,
boiling point 185°C to 187°C at 2.2 mm. | [Therapeutic Function]
Antihistaminic |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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