| Identification | Back Directory | [Name]
4-((4-ethylpiperazin-1-yl)Methyl)-3-(trifluoroMethyl)aniline | [CAS]
630125-91-6 | [Synonyms]
4-((4-ethylpiperazin-1-yl)Methyl)-3-(trifluoroMethyl)aniline
4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)aniline
Benzenamine, 4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)- | [Molecular Formula]
C14H20F3N3 | [MDL Number]
MFCD09909923 | [MOL File]
630125-91-6.mol | [Molecular Weight]
287.32 |
| Chemical Properties | Back Directory | [Boiling point ]
344.9±42.0 °C(Predicted) | [density ]
1.195±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
soluble in Dichloromethane; | [form ]
Solid | [pka]
7.76±0.10(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzenamine is one of the key reactants with N-[1-(4-Aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide used in the synthesis of a pyrrolo[3,2-c]pyridine derivative [N-[1-[4-[[[[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide (I)], an anticancer diarylurea derivative with multiple-kinase inhibitory effect; Also, it is an intermediate used in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N''-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells. |
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