| Identification | Back Directory | [Name]
TBPB | [CAS]
634616-95-8 | [Synonyms]
TBPB(1%EA)
1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
1,3-Dihydro-1-[1'-[(2-methylphenyl)methyl][1,4'-bipiperidin]-4-yl]-2H-benzimidazol-2-one
2H-BenziMidazol-2-one, 1,3-dihydro-1-[1'-[(2-Methylphenyl)Methyl][1,4'-bipiperidin]-4-yl]- | [Molecular Formula]
C25H32N4O | [MDL Number]
MFCD22666590 | [MOL File]
634616-95-8.mol | [Molecular Weight]
404.55 |
| Chemical Properties | Back Directory | [density ]
1.193±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL (clear solution; warmed) | [form ]
powder | [pka]
12.04±0.30(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
TBPB is an allosteric M1 muscarinic acetylcholine receptor activator that regulates amyloid processing and produces antipsychotic-like activity in rats. | [Biological Activity]
TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. It activates M1 through an allosteric site rather than the orthosteric acetylcholine binding sitewhich is likely critical for its selectivity. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memoryincluding hippocampuscortexand striatum. M1 activation is a proposed mechanism for increasing information processing in disease statessuch as Alzheimerμs. M1 agonists are being studied as potential therapeutic agents to tre at Alzheimer′s disease and the cognitive and negative symptoms of schizophrenia. |
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D&C Chemicals
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+86-21-58447131 |
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www.chemicalbook.com/ShowSupplierProductsList16963/0.htm |
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