| Identification | Back Directory | [Name]
AEG 3482 | [CAS]
63735-71-7 | [Synonyms]
AEG 3482
AEG 3482 >=98% (HPLC)
6-PHENYLIMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE
IMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE, 6-PHENYL-
6-PHENYL-IMIDAZO[2,1-B][1,3,4]THIADIAZOLE-2-SULFONIC ACID AMIDE | [Molecular Formula]
C10H8N4O2S2 | [MDL Number]
MFCD02064987 | [MOL File]
63735-71-7.mol | [Molecular Weight]
280.33 |
| Chemical Properties | Back Directory | [density ]
1.75 | [storage temp. ]
Store at RT | [solubility ]
DMSO: ≥15mg/mL | [form ]
powder | [pka]
5.05±0.60(Predicted) | [color ]
faint yellow to dark yellow |
| Hazard Information | Back Directory | [Uses]
AEG 3482 is an antiapoptotic compound that inhibits Jun Kinase Activity (JNK) and cell death through induced expression of heat shock protein 70. AEG 3482 shows possible use in the treatment of neurological disorders. | [Definition]
ChEBI: 6-phenyl-2-imidazo[2,1-b][1,3,4]thiadiazolesulfonamide is a member of imidazoles. | [Biological Activity]
Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC 50 = 20 μ M). | [References]
[1]salehi ah, morris sj, ho wc, etal. , aeg3482 is an antiapoptotic compound that inhibits jun kinase activity and cell death through induced expression of heat shock protein 70. chem biol. 2006 feb;13(2):213-23.
[2] gallo ka. targeting hsp90 to halt neurodegeneration. chem biol. 2006 feb;13(2):115-6. |
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BOC Sciences
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Energy Chemical
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InvivoChem
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