| Identification | Back Directory | [Name]
Cadralazine | [CAS]
64241-34-5 | [Synonyms]
DC-26
Cadral
DC 826
ISF-469
ISF 2469
Presmode
Cadraten
Cadrilan
CGP 18684E
Cadralazine
2-[6-[Ethyl
Cardralazine
Cadralazine USP/EP/BP
(2-hydroxypropyl)amino]-3-pyridazinyl]hydrazinecarboxylic acid ethyl ester
Ethyl 2-(6-(ethyl(2-hydroxypropyl)aMino)pyridazin-3-yl)hydrazinecarboxylate
Ethyl 2-(6-(ethyl(2-hydroxypropyl)amino)pyridazin-3-yl)hydrazine-1-carboxylate
3-[6-[N-Ethyl-N-(2-hydroxypropyl)amino]pyridazin-3-yl]carbazic acid ethyl ester
2-[6-[Ethyl(2-hydroxypropyl)amino]pyridazin-3-yl]hydrazine-1-carboxylic acid ethyl ester
HYDRAZINECARBOXYLIC ACID, 2-[6-[ETHYL(2-HYDROXYPROPYL)AMINO]-3-PYRIDAZINYL]-, ETHYL ESTER | [Molecular Formula]
C12H21N5O3 | [MDL Number]
MFCD00865833 | [MOL File]
64241-34-5.mol | [Molecular Weight]
283.33 |
| Chemical Properties | Back Directory | [Melting point ]
160-162° | [Boiling point ]
425.88°C (rough estimate) | [density ]
1.1585 (rough estimate) | [refractive index ]
1.6500 (estimate) | [storage temp. ]
2-8°C | [solubility ]
DMSO : 250 mg/mL (882.36 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
6.0(at 25℃) | [color ]
White to off-white | [CAS DataBase Reference]
64241-34-5 |
| Hazard Information | Back Directory | [Description]
Cadralazine is a vasodilatory antihypertensive reportedly better-tolerated and
longer-acting than hydralazine. It is useful as a second-line treatment in the management
of hypertension. | [Originator]
ISF;（Smith Mine) (Italy) | [Definition]
ChEBI: Cadralazine is an organic molecular entity. | [Brand name]
Cadraten 21 cpr 20 mg;Cadraten 30 cpr 10 mg;Cadraten 30 cpr 15 mg;Cadratin;Cadrilan. | [World Health Organization (WHO)]
Cadralazine, a peripheral vasodilator, was introduced in 1989 for
the treatment of arterial hypertension.In 1992, its association with serious side
effects led to the refusal of registration in Norway. Animal experiments have
demonstrated drug-related impairment of thyroid function as well as potential carcinogenicity and genotoxicity. It remains available for treatment of hypertension
in Italy. | [storage]
Store at -20°C |
| Safety Data | Back Directory | [Toxicity]
LD50 in rats, dogs (mg/kg): 269, approx 400 i.v.; 2060, >2000 orally (Semeraro); in mice (mg/kg): 700 i.p. (Parravicini) |
|
| Company Name: |
LGM Pharma
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1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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