| Identification | Back Directory | [Name]
2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether | [CAS]
652142-94-4 | [Synonyms]
STING Agonist 1a
2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether | [Molecular Formula]
C19H11Cl2N5O | [MOL File]
652142-94-4.mol | [Molecular Weight]
396.23 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: slightly soluble,DMSO: slightly soluble,PBS (pH 7.2): slightly soluble | [form ]
A crystalline solid | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Biological Activity]
STING agonist 1a is an agonist of stimulator of interferon genes (STING).1 It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50 = 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . | [References]
1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screeningBioorg. Chem.100103958(2020)
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