| Identification | Back Directory | [Name]
2-(2,4-dichlorophenyl)-5-nitro-3H-benzoimidazole | [CAS]
6638-24-0 | [Synonyms]
NSC47924
2-(2,4-dichlorophenyl)-5-nitro-3H-benzoimidazole
2-Naphthalenol, 1-[[(4-methoxyphenyl)amino]methyl]- | [Molecular Formula]
C18H17NO2 | [MOL File]
6638-24-0.mol | [Molecular Weight]
279.33 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming) | [form ]
solid | [color ]
Yellow | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| Hazard Information | Back Directory | [Description]
NSC-47924 (6638-24-0) is a potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 μM).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM (IC50=19.35 μM) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3 | [References]
1) Sierecki et al. (2010), Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase PHLPP by chemical and virtual screening; J. Med. Chem., 53 6899
2) Pesapane et al. (2015), Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion; Oncotarget, 6 18116
3) Samataro et al. (2016), The 37/67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67 kDa LA cell surface localization and interaction with the cellular prion protein; Sci. Rep., 6 24457 |
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