| Identification | Back Directory | [Name]
trimetaphan camsilate | [CAS]
68-91-7 | [Synonyms]
Arfonad
NU-2222
Arphonad
Ro 2-2222
MethioplegiuM
trimetaphan camsilate
Trimetaphan camsylate
TriMetaphan caMphorsulfonate
TRIMETHAPHANCAMPHORSULPHONATE
Trimethaphan camphorsulfonate
trimetaphan camsilate USP/EP/BP
TriMethaphan 10-caMphorsulfonate
1,3-dibenzyl-4,6,7,8,8a,8b-hexahydro-3aH-thieno[5,6]thieno[1,2-b]imidazol-5-ium-2-one:[(1R,4S)-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonate | [EINECS(EC#)]
200-696-8 | [Molecular Formula]
C22H25N2OS.C10H16O4S | [MOL File]
68-91-7.mol | [Molecular Weight]
597.817 |
| Hazard Information | Back Directory | [Definition]
ChEBI: The (S)-camphorsulfonate salt of trimethaphan. | [General Description]
Trimethaphan camsylate,(+)-1,3-dibenzyldecahydro2-oxoimidazo[4,5-c]thieno[1,2-α]-thiolium 2-oxo-10-bornanesulfonate (1:1)(Arfonad), consists of white crystals or a crystalline powderwith a bitter taste and a slight odor. It is soluble inwater and alcohol but only slightly soluble in acetone andether. The pH of a 1% aqueous solution is 5.0 to 6.0. | [Clinical Use]
This ganglionic blocking agent is short acting and isused for certain neurosurgical procedures in which excessivebleeding obscures the operative field. Certain craniotomiesare included among these operations. The actionof the drug is direct vasodilation, and because of its transientaction, it is subject to minute-by-minute control.This fleeting action, however, makes it useless for hypertensivecontrol. The drug is ineffective when given orally.The usual route of administration is intravenous.Trimethaphan camsylate is indicated in the treatment ofhypertensive emergencies to reduce blood pressure rapidly.These emergencies may include pulmonary hypertensionassociated with systemic hypertension and acutedissecting aneurysm. |
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Leancare Ltd.
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+33 962096793 |
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www.leancare.co.uk |
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