| Identification | Back Directory | [Name]
AICAR (phosphate) | [CAS]
681006-28-0 | [Synonyms]
AICAR (phosphate)
Acadesine phosphate
AICAR phosphate, >98%
AICA Riboside phosphate)
AICAR (Acadesine) phosphate
AICAR phosphate
(Acadesine phosphate
ACADESINE PHOSPHATE;AICA RIBOSIDE PHOSPHATE
5-Amino-1-ribosylimidazole-4-carboxamide phosphate | [Molecular Formula]
C9H17N4O9P | [MDL Number]
MFCD23726600 | [MOL File]
681006-28-0.mol | [Molecular Weight]
356.226 |
| Hazard Information | Back Directory | [Biological Activity]
aicar phosphate （acadesine）is an activator of ampk [1].aicar phosphate has been reported to induce apoptosis in a dose-dependent fashion and that the ec50 value is 380±60μm on the viability assay of b-cll cells. in addition, aicar phosphate has been revealed to induce caspase activation and cytochrome c release from mitochondria in b-cll cells. furthermore, aicar phosphate has shown that uptake and phosphorylation are required to induce apoptosis and activate ampk. apart from these, aicar phosphate (2-4 mm) has shown to only slightly affects the viability of t cells from b-cll patients, aicar phosphate (0.5 mm) has been noted to remarkedly reduces viability of b cells but not t cells [1]. | [References]
[1] campàs c1, lopez jm, santidrián af, barragán m, bellosillo b, colomer d, gil j. acadesine activates ampk and induces apoptosis in b-cell chronic lymphocytic leukemia cells but not in t lymphocytes. blood. 2003 may 1;101(9):3674-80. epub 2003 jan 9. |
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