| Identification | Back Directory | [Name]
3β-Hydroxyurs-12,19-dien-28-oic acid | [CAS]
6812-98-2 | [Synonyms]
Ursa-12
3β-Hydroxyurs-12
Sanguisorbigenin
Tomentosolic acid
19-dien-28-oic acid
19-Dehydroursolic acid
Ursa-12,19-dien-28-oic acid
3β-Hydroxyurs-12,19-dien-28-oic acid
3β-Hydroxyurs-12,19-dien-28-oic acid
Ursa-12,19-dien-28-oic acid, 3-hydroxy-, (3β)- | [Molecular Formula]
C30H46O3 | [MDL Number]
MFCD34470924 | [MOL File]
6812-98-2.mol | [Molecular Weight]
454.7 |
| Chemical Properties | Back Directory | [Melting point ]
267-268 °C (decomp) | [Boiling point ]
563.4±50.0 °C(Predicted) | [density ]
1.11±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.49±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant S. aureus (MRSA)[1].
The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL[1]. The expression of blaR1, mecA and blaZ is significantly inhibited in MRSA in a dose-dependent manner when it is treated with sub-MIC (1.56-6.25 μg/mL) concentrations of Sanguisorbigenin. Sanguisorbigenin remarkably reduces the gene expression of mecA. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decrease PBP2a expression[1]. | [References]
[1]. S Wang, et al. Antibacterial activity and synergy of antibiotics with sanguisorbigenin isolated from Sanguisorba officinalis L. against methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol. 2021 Mar;72(3):238-244. |
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