| Identification | Back Directory | [Name]
5-(2-BENZOTHIAZOLYL)-3-ETHYL-2-(-(METHY | [CAS]
681281-88-9 | [Synonyms]
5-(2-BENZOTHIAZOLYL)-3-ETHYL-2-(-(METHY
Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem
6-(2-Benzothiazolyl)-1-ethyl-2-[2-(methylphenylamino)ethenyl]-3-phenyl-1H-benzimidazolium iodide
6-benzothiazol-2-yl-1-ethyl-2-[2-(methyl-phenyl-amino)-vinyl]-3-phenyl-3H-benzoimidazol-1-ium iodide
5-(Benzo[d]thiazol-2-yl)-3-ethyl-2-(2-(methyl(phenyl)amino)vinyl)-1-phenyl-1H-benzo[d]imidazol-3-ium iodide
(E)-5-(benzo[d]thiazol-2-yl)-3-ethyl-2-(2-(methyl(phenyl)amino)vinyl)-1-phenyl-1H-benzo[d]imidazol-3-ium iodide | [Molecular Formula]
C31H27N4S.I | [MDL Number]
MFCD00570739 | [MOL File]
681281-88-9.mol | [Molecular Weight]
614.548 |
| Hazard Information | Back Directory | [Uses]
Akt Inhibitor IV is an Inhibitor of Akt protein kinase | [Biological Activity]
akt inhibitor iv is an inhibitor of akt activation that inhibits akt-mediated nuclear export of forkhead box class o transcription factor 1a (foxo1a; ic50 = 625 nm) and reduces phosphorylation of akt at ser473 and thr308 in a dose-dependent manner. akt inhibitor iv inhibits replication of parainfluenza virus 5 (piv5) in hela cells (ic50 = 520 nm). it also reduces the growth of cancer cells (ic50 = 0.3 μm for both jurkat and hela cells) via a reduction in mitochondrial polarization and increased production of reactive oxygen species (ros). |
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