| Identification | Back Directory | [Name]
BC 11-38 | [CAS]
686770-80-9 | [Synonyms]
6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one
3-phenyl-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one
Thieno[3,2-d]pyrimidin-4(3H)-one, 6,7-dihydro-3-phenyl-2-(propylthio)- | [Molecular Formula]
C15H16N2OS2 | [MOL File]
686770-80-9.mol | [Molecular Weight]
304.43 |
| Chemical Properties | Back Directory | [storage temp. ]
RT | [solubility ]
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 14 mg/ml with warming). | [form ]
solid | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
BC-11-38 (686770-80-9) is a? potent and selective inhibitor of phosphodiesterase PDE11 (IC50=0.28 μM).1? IC50s for PDE1-10 are greater than 100 μM. Restores the ability of p54nrb / NONOKD cells to generate cAMP in response to ACTH stimulation and the production of cortisol and DHEA in response to cAMP signaling.2 | [Uses]
BC 11-38 is a selective inhibitor of phosphodiesterase 11. Potent PDE-11 inhibitor | [storage]
Store at -20°C | [References]
1) Ceyhan et al. (2012), Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen; Chem. Biol., 19 155
2) Lu and Sewer (2015), p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation; Mol. Cell. Biol. 35 1223 |
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