6871-21-2

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6871-21-2 Structure

Identification	Back Directory
[Name] asimilobine
[CAS] 6871-21-2
[Synonyms] asimilobine R-(-)-asimilobine 1-Methoxy-6abeta-noraporphin-2-ol (R)-5,6,6a,7-Tetrahydro-1-methoxy-4H-dibenzo[de,g]quinolin-2-ol 4H-Dibenzo[de,g]quinolin-2-ol, 5,6,6a,7-tetrahydro-1-methoxy-, (6aR)-
[Molecular Formula] C17H17NO2
[MDL Number] MFCD28385980
[MOL File] 6871-21-2.mol
[Molecular Weight] 267.32

Chemical Properties	Back Directory
[Melting point ] 177-179℃ (acetone )

Hazard Information	Back Directory
[Uses] Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[1][2].
[Definition] ChEBI: A natural product found in Annona glabra.
[IC 50] Plasmodium; Dopamine Receptor; serotonergic receptor
[References] [1] N Shoji, et al. Asimilobine and Lirinidine, Serotonergic Receptor Antagonists, From Nelumbo Nucifera. J Nat Prod. Jul-Aug 1987;50(4):773-4. DOI:10.1021/np50052a044 [2] Chun-Mei Jin, et al. Effects of Asimilobine on Dopamine Biosynthesis and l-DOPA-induced Cytotoxicity in PC12 Cells. J Asian Nat Prod Res. Jul-Aug 2008;10(7-8):747-55. DOI:10.1080/10286020802030892

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