| Identification | Back Directory | [Name]
SB-656933 | [CAS]
688763-65-7 | [Synonyms]
SB-656933
SB-656933AAF
SB-656933-AAF
Elubrixin HCl
SB-656933 AAF
Elubrixin hydrochloride
1-(2-chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea:hydrochloride
1-(2-Chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-(piperazine-1-sulfonyl)phenyl]urea (Hydrochloride) | [Molecular Formula]
C17H18Cl3FN4O4S | [MDL Number]
MFCD25977081 | [MOL File]
688763-65-7.mol | [Molecular Weight]
499.76 |
| Hazard Information | Back Directory | [Description]
Elubrixin, also known as SB-656933 or SB-656933-AAF, is a interleukin 8 inhibitor and CXCR2 selective antagonist, which is potentially useful for Inflammatory bowel disease therapies. Elubrixin inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. demonstrates dose-dependent effects on neutrophil activation and recruitment within a well-tolerated dose range. SB-656933 may be an effective agent in neutrophil-predominant diseases. |
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