| Identification | Back Directory | [Name]
C18 Globotriaosylceramide (d18:1/18:0) | [CAS]
69283-33-6 | [Synonyms]
Octadecanoyl-ceramide trihexoside
C18 Globotriaosylceramide (d18:1/18:0) | [Molecular Formula]
C54H101NO18 | [MOL File]
69283-33-6.mol | [Molecular Weight]
1052.38 |
| Hazard Information | Back Directory | [Description]
C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. C18 globotriaosylceramide also accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. [Matreya, LLC. Catalog No. 1529] | [Definition]
ChEBI: Alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1/18:0) is a glycotriaosylceramide having alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl as the glycotriaosyl component attached to the Cer(d18:1/18:0). It has a role as a mouse metabolite. It is functionally related to an octadecanoic acid. |
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Alfa Chemistry
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