| Identification | Back Directory | [Name]
GALANTHAMINE HYDROBROMIDE | [CAS]
69353-21-5 | [Synonyms]
NIVALIN
1990/4/4
nivaline
NIVALIN, HBR
zocin-6-olhbr
GALANTAMINE HBR
GALANTHAMINE HBR
jilkonhydrobromide
Galantamine N-D3 HBr
Galantamine O-D3 HBr
lycoreminehydrobromide
GALANTAMINE HYDROBROMIDE
nivaline(pharmaceutical)
GALANTHAMIDE HYDROBROMIDE
galanthaminehydrogenbromide
nivaline(c17pharmaceutical)
Nootropics Power Galanthamine
GALANTHAMINE HYDROBROMIDE USP/EP/BP
Galantamine natural for system suitability
Galanthamine HBr (Galantamine Hydrobromide)
Galantamine synthetic for system suitability
Galanthamine, Hydrobromide - CAS 69353-21-5 - Calbiochem
High purity CAS 69353-21-5 GALANTHAMINE HYDROBROMIDE in stock
1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-benzofuro(4,3,2-efg)(2)benza
3,2-efg)(2)benzazocin-6-ol,1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-benzofuro(
1,2,3,4,6,7,7a,11c-Octahydro-9-methoxy-2-methylbenzofuro[4,3,2-efg]-2-benzazocin-6-ol hydrobromide
2,3,3a,8,9,10,11,11b-Octahydro-5-methoxy-9-methylbenzofuro[4,3,2-efg][2]benzazocin-2-ol hydrobromide
5-Methoxy-9-methyl-2,3,3a,3a1,8,9,10,11-octahydro-4-oxa-9-azacycloocta[def]fluoren-2-ol hydrobromide
4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-6H-BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-6-OL HYDROBROMIDE
Benzofuro[4,3,2-efg][2]benzazocin-2-ol,2,3,3a,8,9,10,11,11b-octahydro-5-Methoxy-9-Methyl-, hydrobroMide (9CI)
5-Methoxy-9-methyl-2,3,3a,3a1,8,9,10,11-octahydro-4-oxa-9-azacycloocta[def]fluoren-2-ol hydrobromide(Galantamine Hydrobromide)
Galantamine HydrobromideQ: What is
Galantamine Hydrobromide Q: What is the CAS Number of
Galantamine Hydrobromide Q: What is the storage condition of
Galantamine Hydrobromide | [EINECS(EC#)]
217-780-5 | [Molecular Formula]
C17H22BrNO3 | [MDL Number]
MFCD00067672 | [MOL File]
69353-21-5.mol | [Molecular Weight]
368.27 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1/PG 3 | [WGK Germany ]
3 | [RTECS ]
DF8075000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III |
| Questions And Answer | Back Directory | [Background]
Galantamine Hydrobromide is the hydrobromide salt form of galantamine, a tertiary alkaloid obtained synthetically or naturally from the bulbs and flowers of Narcissus and several other genera of the Amaryllidaceae family with anticholinesterase and neurocognitive-enhancing activities. Galantamine competitively and reversibly inhibits acetylcholinesterase, thereby increasing the concentration and enhancing the action of acetylcholine (Ach). In addition, galantamine is a ligand for nicotinic acetylcholine receptors, which may increase the presynaptic release of Ach and activate postsynaptic receptors. This agent may improve neurocognitive function in mild and moderate Alzheimer's disease and may reduce abstinence-induced cognitive symptoms that promote smoking relapse[1].
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| Hazard Information | Back Directory | [General Description]
A competitive and reversible inhibitor of acetylcholinesterase. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats. Reported to improve learning and short-term memory in animal models. | [Biochem/physiol Actions]
Primary TargetAcetylcholinesterase | [Clinical Use]
Galantamine, which was introduced in 2001, is an alkaloid found in plants of the family Amaryllidaceae, which includes the daffodil (Narcissus
pseudonarcissus) and snowflake (Leucojum aestivum). It is a reversible inhibitor of AChE, but it does not appear to inhibit butyrylcholinesterase.
Because it is a tertiary amine and can cross the blood-brain barrier, it is indicated for treatment of mild-to-moderate AD and dementia. It has
been used outside the U.S. for more than 30 years as an anticurare agent in anesthesia. Galantamine differs from other cholinesterase
inhibitors, because it allosterically binds to nicotinic receptors, giving it a dual cholinergic action. | [Metabolism]
It is metabolized (75%) by CYP2D6 and
CYP3A4 to afford the normethyl, O-desmethyl, and O-desmethylnormethyl metabolites, along with some other minor metabolites. Unlike tacrine,
galantamine is not associated with hepatotoxicity. Its elimination half-life is 5.7 hours. |
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