| Identification | Back Directory | [Name]
GO 289) | [CAS]
694522-87-7 | [Synonyms]
GO 289)
(EZ)-GO289
GO289
(GO-289
5-Bromo-2-methoxy-4-(((3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl)imino)methyl)phenol
Phenol, 5-bromo-2-methoxy-4-[[[3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl]imino]methyl]-
Inhibitor,cancer,(E/Z)GO289,circadian,(E/Z)-GO-289,cell,clock,rhythms,growth,(E/Z) GO289,phosphorylation,(E/Z)-GO289,Casein Kinase,inhibit | [Molecular Formula]
C17H15BrN4O2S | [MDL Number]
MFCD03718152 | [MOL File]
694522-87-7.mol | [Molecular Weight]
419.3 |
| Chemical Properties | Back Directory | [Boiling point ]
618.0±65.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
7.53±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GO289, is a new potent and highly selective CK2 inhibitor, which strongly lengthens circadian period. It inhibits multiple phsphorylation sites on clock proteins, including PER2 S693. GO289, also exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. | [Biological Activity]
GO289 is a highly potent and selective casein kinase CK2 (CKII) inhibitor (IC50 = 7 nM/CK213 μM/PIM2>50 μM/CLK2; <50% inhibition of CK1α/δ/γ and 56 other kinases at 5 μM) th at targets CK2-specific residues (CK2α V66M163and H160) with more overall interactions at the CK2 ATP-binding pocket than TBBDM at & CX-4945. GO289 selectively inhibits cellular CK1 substrates phosphorylation (0.8-8 μM; HEK293TU2OS)including clock proteins PER2CRY1CLOCK & BMAL1and displays circadian period-lengthening (Bmal1-dLuc USOS EC50 = 3.3 μM) as well as growth inhibitory potency in CK2-dependent human renal cell carcinoma (RCC) cultures. |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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