| Identification | Back Directory | [Name]
2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE | [CAS]
70006-24-5 | [Synonyms]
ABT 724
ABT 724 TRIHYDROCHLORIDE
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole
1H-Benzimidazole, 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-
2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE | [Molecular Formula]
C17H19N5 | [MDL Number]
MFCD08703101 | [MOL File]
70006-24-5.mol | [Molecular Weight]
293.37 |
| Hazard Information | Back Directory | [Uses]
ABT 724 trihydrochloride is a potent dopamine D4 receptor agonist. ABT 724 is used in pharmacology systems for treating ocular disorders. | [Definition]
ChEBI: 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole is a member of pyridines and a member of piperazines. | [Biological Activity]
Potent dopamine D 4 receptor partial agonist (EC 50 = 12.4 nM; 61% efficacy vs. dopamine). Has no agonist activity at D 2 receptors (EC 50 > 10 μ M). Selective in rats in vivo : produces penile erection following i.c.v. administration; increases intracavernosal pressure and potentiates the proerectile effects of sildenafil following s.c. administration. Displays minimal side effects. |
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