| Identification | Back Directory | [Name]
(S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid | [CAS]
70396-18-8 | [Synonyms]
Boc-Val-Ala
Boc-L-Valyl- L-Alanin
N-Boc-L-valyl- L-alanine
(Tert-Butoxy)Carbonyl Val-Ala-OH
(tert-Butoxycarbonyl)-L-valyl-L-alanine
L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-
(S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid
(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]propanoic acid | [Molecular Formula]
C13H24N2O5 | [MDL Number]
MFCD22381612 | [MOL File]
70396-18-8.mol | [Molecular Weight]
288.34 |
| Chemical Properties | Back Directory | [Boiling point ]
493.3±30.0 °C(Predicted) | [density ]
1.121±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
3.50±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Boc-Val-Ala-OH is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The Boc group can be deprotected under mild acidic conditions to form the free amine. |
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