| Identification | Back Directory | [Name]
(3S,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol | [CAS]
70741-38-7 | [Synonyms]
8DHC
Δ5,8 Sterol
Δ5,8-Cholest-dienol
8-Dehydrocholesterol
Cholesta-5,8-dien-3β-ol
8(9)-dehydrocholesterol
cholesta-5,8(9)-dien-3-ol
cholesta-5,8-dien-3 beta-ol
Cholesta-5,8-dien-3-ol, (3β)-
CHOLESTA-5,8(9)-DIEN-3-OL;8(9)-DEHYDROCHOLESTEROL
(3S,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol | [Molecular Formula]
C27H44O | [MDL Number]
MFCD28359037 | [MOL File]
70741-38-7.mol | [Molecular Weight]
384.64 |
| Chemical Properties | Back Directory | [Melting point ]
147-148 °C(Solv: chloroform (67-66-3); acetone (67-64-1)) | [Boiling point ]
492.1±44.0 °C(Predicted) | [density ]
1.00±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
15.00±0.70(Predicted) | [color ]
White to Pale Yellow |
| Hazard Information | Back Directory | [Description]
8-dehydro Cholesterol (8-DHC) is an isomer of the cholesterol precursor 7-DHC . It accumulates in tissues and plasma in patients with Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in DHCR7, the gene encoding 3β-hydroxysterol-Δ7-reductase, and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. 8-DHC levels are increased in serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 . | [Uses]
8-Dehydrocholesterol is an intermediate in the synthesis of Zymostenol, which is the derivative of Zymosterol (Z701520), an sterol intermediate in the biosynthesis of cholesterol (C432501). | [Definition]
ChEBI: 8-Dehydrocholesterol is a steroid. |
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