ChemicalBook--->CAS DataBase List--->709031-78-7

709031-78-7

709031-78-7 Structure

709031-78-7 Structure
IdentificationBack Directory
[Name]

Saxagliptin hydrochloride
[CAS]

709031-78-7
[Synonyms]

Saxaint-S
Saxagliptin HCL salt
Saxagliptin hydrochloride
(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile monohydrochloride
[EINECS(EC#)]

696-124-3
[Molecular Formula]

C18H25N3O2.HCl
[MDL Number]

MFCD22572334
[MOL File]

709031-78-7.mol
[Molecular Weight]

351.88
Chemical PropertiesBack Directory
[Melting point ]

>219°C
[storage temp. ]

-20°C
[solubility ]

Soluble in DMSO (20 mg/ml)
[form ]

solid
[color ]

White
[Stability:]

Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
[InChIKey]

TUAZNHHHYVBVBR-PMEPUXBANA-N
[SMILES]

[C@@H](C12CC3CC(CC(C3)(O)C1)C2)(N)C(N1[C@@H](C[C@@H]2C[C@H]12)C#N)=O.Cl |&1:0,15,17,19,r|
Hazard InformationBack Directory
[Description]

Saxagliptin (709031-78-7) is a clinically useful DPPIV inhibitor for the treatment of diabetes.1 ?Human DPP-IV Ki = 0.6 nM.2
[Uses]

Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.
[storage]

Store at -20°C
[References]

Tahrani et al. (2009) Saxagliptin: a new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus; Adv. Ther. 26 249 Augeri et al. (2005) Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes; J. Med. Chem. 48 5025
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