| Identification | Back Directory | [Name]
HYDROMORPHONE HYDROCHLORIDE | [CAS]
71-68-1 | [Synonyms]
HYDROMORPHONE HCL
dilaudidhydrochloride
HYDROMORPHONE HYDROCHLORIDE
XHILEZUETWRSHC-NRGUFEMZSA-N
Hydromorphine hydrochloride
HYDROMORPHONEHYDROCHLORIDE,USP
dihydromorphinonehydrochloride
Hydromorphone hydrochloride salt
Morphinone, dihydro-, hydrochloride
hydromorphone hydrochloride solution
HydroMorphone Hydrochloride (CII), USP
Hydromorphone Hydrochloride CII (50 mg)
HYDROMORPHONE HYDROCHLORIDE OPIATE ANALG ESIC
HYDROMORPHONE HYDROCHLORIDE METHANOL*SOL UTION
hydromorphone hydrochloride--dea*schedule ii item
4,5-alpha-epoxy-3-hydroxy-17-methylmorphinan-6-onehydrochloride
(5α)-4,5-epoxy-3-hydroxy-17-methyl-morphinan-6-one hydrochloride
Morphinan-6-one, 4,5.alpha.-epoxy-3-hydroxy-17-methyl-, hydrochloride
Morphinan-6-one,4,5-epoxy-3-hydroxy-17-Methyl-, hydrochloride (1:1), (5a)-
Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, hydrochloride, (5.alpha.)-
morphinan-6-one,4,5-alpha-epoxy-3-hydroxy-17-methyl-,hydrochloride,(5’-alpha
(4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one hydrochloride | [EINECS(EC#)]
200-762-6 | [Molecular Formula]
C17H20ClNO3 | [MDL Number]
MFCD03427563 | [MOL File]
71-68-1.mol | [Molecular Weight]
321.8 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Analgesic (narcotic). Preparation by electrolytic reduction of Morphine.
Controlled substance (opiate). | [Description]
Hydromorphone hydrochloride is a pure opioid agonist with the principal therapeutic activity of analgesia. It has an analgesic potency approximately two to eight times greater than that of morphine and has a rapid onset of action. A significant feature of the analgesia is that it can occur without loss of consciousness.
? | [Biochem/physiol Actions]
Narcotic opiate analgesic; μ opioid receptor agonist. | [Clinical Use]
Hydromorphone is a potent μ agonist (eight times greater than morphine) that is used to treat
severe pain. It is available in intramuscular, intravenous, subcutaneous, oral, and rectal dosage
forms. Like all strong μ agonists, hydromorphone is addicting and is a Schedule II drug.
Hydromorphone has an oral:parenteral potency ratio of 5:1. The plasma half-lives after parenteral
and oral dosage are 2.5 and 4 hours, respectively. | [Drug interactions]
Potentially hazardous interactions with other drugs
Alcohol: can cause dose dumping with sustained
release preparations.
Analgesics: possible opioid withdrawal effects with
buprenorphine and pentazocine.
Antidepressants: possible CNS excitation or
depression with MAOIs - avoid concomitant use
and for 2 weeks after stopping MAOI; possible
CNS excitation or depression with moclobemide;
increased sedative effects with tricyclics.
Antihistamines: increased sedative effects with
sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative
effects.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate
- avoid. | [Metabolism]
Hydromorphone undergoes extensive firstpass
metabolism. It is extensively metabolised
by glucuronidation in the liver and excreted in
the urine mainly as conjugated hydromorphone,
dihydroisomorphine, and dihydromorphine. |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [Safety Statements ]
16-36/37-45 | [RIDADR ]
UN 1230 3/PG 2
| [WGK Germany ]
3
| [RTECS ]
QD2625000
| [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
2939110000 | [Safety Profile]
Poison by
subcutaneous and intravenous routes.
Experimental teratogenic effects. A
powerful analgesic. When heated to
decomposition it emits very toxic fumes of
NOx and HCl. See also MORPHINE. | [Toxicity]
LD50 in mice (mg/kg): 61-96 i.v. (Buchwald, Eadie) |
|