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714240-31-0

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714240-31-0 Structure

714240-31-0 Structure
IdentificationBack Directory
[Name]

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one
[CAS]

714240-31-0
[Synonyms]

NCGC00029283
3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one
[Molecular Formula]

C18H12FN3O3
[MDL Number]

MFCD05729526
[MOL File]

714240-31-0.mol
[Molecular Weight]

337.3
Chemical PropertiesBack Directory
[density ]

1.365±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

9.37±0.70(Predicted)
[color ]

White to yellow
Spectrum DetailBack Directory
[Spectrum Detail]

3-(5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2(1H)-one(714240-31-0)1HNMR
Hazard InformationBack Directory
[Biological Activity]

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1]. NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells[1].
[References]

[1]. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525.
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