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71636-61-8

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71636-61-8 Structure

71636-61-8 Structure
IdentificationBack Directory
[Name]

(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
[CAS]

71636-61-8
[Synonyms]

sk&f81297
(±)-6-Chloro-PB
SKF 81297 hydrobromi
SKF 81297 HYDROBROMIDE
(+/-)-SKF-81297 HYDROBROMIDE
(+/-)-6-CHLORO-PB HYDROBROMIDE
(+-)-6-CHLORO-PB HYDROBROMIDE (+-)-SKF-8 1297, HCL
2,3,4,5-Tetrahydro-6-chloro-1-phenyl-1H-3-benzazepine-7,8-diol
6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol
6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol
1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-
6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepinehydrobromide
6-CHLORO-2,3,4,5-TETRAHYDRO-1-PHENYL-1H-3-BENZAZEPINE-7,8-DIOL HYDROBROMIDE
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
(±)-SKF-81297 hydrobromide, (±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
[Molecular Formula]

C16H17BrClNO2
[MDL Number]

MFCD00153782
[MOL File]

71636-61-8.mol
[Molecular Weight]

370.67
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at +4°C
[solubility ]

H2O: 1.7 mg/mL
[form ]

solid
[color ]

gray
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

22-26-36
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal?regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.
[Definition]

ChEBI:9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol is a benzazepine.
[Biological Activity]

Dopamine D 1 -like receptor agonist. Centrally active following systemic administration in vivo .
[Biochem/physiol Actions]

(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist.
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