| Identification | Back Directory | [Name]
LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE | [CAS]
71800-36-7 | [Synonyms]
1-9-Kallidin
des-arg(10)-kallidi
(DES-ARG10)-KALLIDIN
Lys-[Des-Arg9]Bradyk
kallidin, des-Arg(10)-
LYS-(DES-ARG9)-BRADYKININ
LYSYL-DES-ARG9-BRADYKININ
[DES-ARG9,LYS0]-BRADYKININ
[LYS0, DES-ARG9]-BRADYKININ
LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE
H-Lys-Arg-Pro-Pro-Gly-Per-Pro-Phe-OH
H-LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-OH
LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE USP/EP/BP
LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE: KRPPGFSPF
Lys-(Des-Arg9)-Bradykinin
(Des-Arg10)-Kallidin | [Molecular Formula]
C50H73N13O11 | [MDL Number]
MFCD00079826 | [MOL File]
71800-36-7.mol | [Molecular Weight]
1032.2 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [form ]
Powder | [pka]
3.56±0.10(Predicted) | [Water Solubility ]
Soluble to 1 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
[Lys-des-Arg9]-Bradykinin has been used as a B1R agonist to investigate the role of B1R in diabetes-induced secondary hemorrhage. | [Biochem/physiol Actions]
[Des-Arg10]-kallidin or [Lys-des-Arg9]-Bradykinin is a bradykinin B1 receptor agonist. It strongly upregulates the B1 receptor and is blocked by a specific protein kinase C inhibitor. The upregulation is correlated with the induction of transcription nuclear factor κB (NF-κB). Elevation of Lys-des[Arg9]–bradykinin because of airway inflammation in asthma patients is known to modify the immune responses. It affects the migration and production of interleukin-12 in monocyte-derived dendritic cells. | [in vivo]
Lys-[Des-Arg9]Bradykinin (1 μg; intra-artenal injection; New Zealand White rabbits) treatment reduces peripheral vascular resistance in LPS-induced rabbits, but the effect is brief (T1/2 is 118-195 s)[3]. | [storage]
Store at -20°C |
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