| Identification | Back Directory | [Name]
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT | [CAS]
71997-40-5 | [Synonyms]
oATP
adenosine 5'-triphosphate-2',3'-dialdehyde
Adenosine 5′-triphosphate, periodate oxidized
Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem
ADENOSINE 5-TRIPHOSPHATE, PERIODATEOXIDI ZED SODIUM
ADENOSINE 5'-TRIPHOSPHATE-2', 3'-DIALDEHYDE SODIUM SALT
Adenosine 5`-triphosphate sodiuM salt periodate oxidized
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT | [Molecular Formula]
C10H13N5NaO13P3 | [MDL Number]
MFCD00056956 | [MOL File]
71997-40-5.mol | [Molecular Weight]
527.15 |
| Hazard Information | Back Directory | [Uses]
Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:
- as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
- as a nonspecific agonist to assess the activity of P2×7-R by the mobilization of Ca2+
- to evaluate the physiological significance of elevated intracellular ATP levels
- increased?P2rx7?expression for osteoclastogenesis in?Flcn-deficient cells
| [General Description]
A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (?100 μM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts. | [Biochem/physiol Actions]
Reversible: no |
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