| Identification | Back Directory | [Name]
methyl 2-[[(diethylamino)acetyl]amino]-3-methylbenzoate monohydrochloride | [CAS]
7210-92-6 | [Synonyms]
Baycaine
Tolycaine hydrochloride
LIWOWASNSWUKPF-UHFFFAOYSA-N
methyl 2-[[2-(diethylamino)acetyl]amino]-3-methylbenzoate,hydrochloride
methyl 2-[[(diethylamino)acetyl]amino]-3-methylbenzoate monohydrochloride
Benzoic acid,2-[[2-(diethylamino)acetyl]amino]-3-methyl-, methyl ester, hydrochloride (1:1) | [EINECS(EC#)]
230-590-7 | [Molecular Formula]
C15H23ClN2O3 | [MOL File]
7210-92-6.mol | [Molecular Weight]
314.808 |
| Chemical Properties | Back Directory | [Melting point ]
139-140.5° | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Originator]
Tolycaine
Hydrochloride,ZYF Pharm Chemical | [Uses]
Tolycaine Hydrochloride is an anesthetic drug. | [Definition]
ChEBI: Tolycaine hydrochloride is an amidobenzoic acid. | [Manufacturing Process]
A suspension of 40 g 2-amino-3-methylbenzoic acid methyl ester in 125 ml of
benzene was added 125 ml of saturated solution of sodium acetate and then
at 0-5°C was added 37 g chloracetylchloride. The mixture was stirred for 1
hour at room temperature. The mixture was filtered. The organic layer was
with 10% solution of potassium carbonate and dries under calcium chloride.
By distillation of the mixture was obtained 15 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester; melting point 86-87.5°C (crystallization from
a mixture acetic acid and ligroin); yield 21.8 g.
A mixture of 16 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl
ester and 10 g diethyl amine in benzene was refluxed for 5 hours. After
cooling the diethyl amine hydrochloride was deleted by filtration. The organic
layer was washed with 2 N hydrochloric acid. To the solution was added
potassium carbonate. The product was extracted with ether and distilled. | [Therapeutic Function]
Local anesthetic |
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