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72702-95-5

72702-95-5 Structure

72702-95-5 Structure
IdentificationBack Directory
[Name]

STATIL
[CAS]

72702-95-5
[Synonyms]

STATIL
MK-538
ICI-plc
ICI-128436
Ponalrestat
Ponalrestat (MK-538
[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID
Ponalrestat Statil
3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL)
2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid
3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid
[Molecular Formula]

C17H12BrFN2O3
[MDL Number]

MFCD00204117
[MOL File]

72702-95-5.mol
[Molecular Weight]

391.19
Chemical PropertiesBack Directory
[Melting point ]

184-186℃ (DEC.)
[density ]

1.60
[storage temp. ]

Store at RT
[solubility ]

DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL
[form ]

A crystalline solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36/37/39
Hazard InformationBack Directory
[Description]

Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F by human cultured preadipocytes.
[Uses]

Inhibitor (aldose reductase).
[Definition]

ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines.
[Biological Activity]

Potent aldose reductase inhibitor.
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