ChemicalBook--->CAS DataBase List--->737763-37-0

737763-37-0

737763-37-0 Structure

737763-37-0 Structure
IdentificationBack Directory
[Name]

360 A iodide
[CAS]

737763-37-0
[Synonyms]

360 A iodide
360A (iodide)
3,3'-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium] diiodide
[Molecular Formula]

I-
[MOL File]

737763-37-0.mol
[Molecular Weight]

126.904
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

insoluble in H2O; insoluble in EtOH; insoluble in DMSO
[form ]

Solid
[color ]

Light yellow to yellow
Spectrum DetailBack Directory
[Spectrum Detail]

360 A iodide(737763-37-0)MS
Hazard InformationBack Directory
[Biological Activity]

360a is a 2,6-pyridine-dicarboxamide derivative displaying strong affinity and selectivity for g-quadruplex structures and selective telomerase inhibition in vitro assays. 360a is a g-quadruplex ligand, which can influence the consequence of g-quadruplex formation and/or stabilization.
[in vitro]

we found a s-phase accumulation in atm-proficient, but not in atm-deficient ebv-lymphocytes treated with 360a before induction of cell death. however, atm status did not modify cell cycle distribution in 360a-treated sv40-fibroblasts and hela cells compared to dmso treated controls [1]. dna-pkcs-dependent nhej was responsible for sister telomere fusions as a direct consequence of g-quadruplex formation and/or stabilization induced by 360a on parental telomere g strands. nhej and hr activation at telomeres altered mitotic progression in treated cells [2]. this compound was shown to display a potent affinity and selectivity for telomeric g-quadruplex dna over duplex dna and to induce delayed growth inhibition in ht1080 tumor cell line [3].
[storage]

Store at -20°C
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