ChemicalBook--->CAS DataBase List--->738-99-8

738-99-8

738-99-8 Structure

738-99-8 Structure
IdentificationBack Directory
[Name]

1,4-Bis(N,N'-diethylene phosphamide)piperazine
[CAS]

738-99-8
[Synonyms]

dipin
Dipine
NSC80096
NSC-80096
NSC 80096
1,4-Bis(N,N'-diethylene phosphamide)piperazine
Piperazine, 1,4-bis[bis(1-aziridinyl)phosphinyl]-
1,4-PIPERAZINEDIHYLBIS(BIS(1-AZIRIDINYL)-PHOPHINEOXIDE
PHOSPHINEOXIDE,1,4-PIPERAZINEDIYLBIS(BIS(1-AZIRIDINYL)-
1,4-Piperazinediylbis[bis(1-aziridinyl)phosphine oxide]
[Molecular Formula]

C12H24N6O2P2
[MDL Number]

MFCD00405583
[MOL File]

738-99-8.mol
[Molecular Weight]

346.31
Chemical PropertiesBack Directory
[Melting point ]

187°
[form ]

solid
[color ]

Crystals from C6H6
Hazard InformationBack Directory
[Uses]

Antineoplastic agent-1 is an alkylating agent and a genotoxic agent that can induce DNA damage. Antineoplastic agent-1 can lead to irreversible damage and progressive death of liver cells due to necroptosis and apoptosis. Antineoplastic agent-1 can cause alkylation damage to hematopoietic cells and stromal cells in the bone marrow. Antineoplastic agent-1 can be used in tumor research[1][2].
[Safety Profile]

Poison by ingestion,intraperitoneal, and subcutaneous routes. Humanmutation data reported. When heated to decomposition itemits very toxic fumes of POx and NOx.
[References]

[1] Factor VM, Radaeva SA, Thorgeirsson SS. Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am J Pathol. 1994 Aug;145(2):409-22. PMID:8053498
[2] Jensen MR, et al. Regulation of cyclin G1 during murine hepatic regeneration following Dipin-induced DNA damage. Hepatology. 1998 Aug;28(2):537-46. DOI:10.1002/hep.510280235
Safety DataBack Directory
[Toxicity]

LD50 orl-mus: 68 mg/kg RPTOAN 36,240,73
738-99-8 suppliers list
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