Identification | Back Directory | [Name]
1,4-Bis(N,N'-diethylene phosphamide)piperazine | [CAS]
738-99-8 | [Synonyms]
dipin Dipine NSC80096 NSC-80096 NSC 80096 1,4-Bis(N,N'-diethylene phosphamide)piperazine Piperazine, 1,4-bis[bis(1-aziridinyl)phosphinyl]- 1,4-PIPERAZINEDIHYLBIS(BIS(1-AZIRIDINYL)-PHOPHINEOXIDE PHOSPHINEOXIDE,1,4-PIPERAZINEDIYLBIS(BIS(1-AZIRIDINYL)- 1,4-Piperazinediylbis[bis(1-aziridinyl)phosphine oxide] | [Molecular Formula]
C12H24N6O2P2 | [MDL Number]
MFCD00405583 | [MOL File]
738-99-8.mol | [Molecular Weight]
346.31 |
Hazard Information | Back Directory | [Uses]
Antineoplastic agent-1 is an alkylating agent and a genotoxic agent that can induce DNA damage. Antineoplastic agent-1 can lead to irreversible damage and progressive death of liver cells due to necroptosis and apoptosis. Antineoplastic agent-1 can cause alkylation damage to hematopoietic cells and stromal cells in the bone marrow. Antineoplastic agent-1 can be used in tumor research[1][2]. | [Safety Profile]
Poison by ingestion,intraperitoneal, and subcutaneous routes. Humanmutation data reported. When heated to decomposition itemits very toxic fumes of POx and NOx. | [References]
[1] Factor VM, Radaeva SA, Thorgeirsson SS. Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am J Pathol. 1994 Aug;145(2):409-22. PMID:8053498 [2] Jensen MR, et al. Regulation of cyclin G1 during murine hepatic regeneration following Dipin-induced DNA damage. Hepatology. 1998 Aug;28(2):537-46. DOI:10.1002/hep.510280235 |
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