| Identification | Back Directory | [Name]
2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl- | [CAS]
748142-06-5 | [Synonyms]
2-Pyrimidinamine, N-[4-(1-methylethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl- | [Molecular Formula]
C19H18N6 | [MOL File]
748142-06-5.mol | [Molecular Weight]
330.39 |
| Hazard Information | Back Directory | [Description]
UNC10112785 is a novel potent inhibitor of CDK8, CDK19, and CDK9 with IC50 at 1.05, 2.67, and 19.9 nM, respectively, causing MYC loss through both transcriptional and posttranslational mechanisms, and suppressing PDAC anchorage-dependent and anchorage-independent growth, inducing the substantial loss of MYC protein in both two-dimensional (2D) and 3D cell cultures. |
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