| Identification | Back Directory | [Name]
acrisorcin | [CAS]
7527-91-5 | [Synonyms]
Akrinol
acrisorcin
Acrisorcina
acrisorcin USP/EP/BP
acridin-9-amine,4-hexylbenzene-1,3-diol
Bis(9-aminoacridinium)salz des hexylresorcine | [EINECS(EC#)]
231-389-7 | [Molecular Formula]
C13H10N2.C12H18O2 | [MDL Number]
MFCD00058389 | [MOL File]
7527-91-5.mol | [Molecular Weight]
388.508 |
| Hazard Information | Back Directory | [Originator]
Aminacrine
hexylresorcinate
,ZYF Pharm | [Uses]
Antifungal. | [Manufacturing Process]
4-Hexylresorcinol 194.0 g is added to a solution composed of 56.1 g
potassium hydroxide in 1.5 L of water with stirring, and the mixture heated to
about 40°C to effect complete solution. The pH of this solution is 12. A second
solution of 9-aminoacridine hydrochloride is prepared as follows: 2 L of water
containing 83 ml of concentrated hydrochloric acid are heated with stirring to
about 80°C. Slowly 194.0 g of 9-aminoacridine are added. Heating is
continued until a clear solution is obtained. About 2 ml of additional
concentrated hydrochloric acid are added in small increments until the solution
is slightly acid (pH of about 6). The 4-hexyl resorcinol solution is now slowly
added under rapid agitation to the 9-aminoacridine hydrochloride solution. A
copious precipitate is formed which, upon :stirring and continued addition of
the 4-hexylresorcinol solution, becomes a creamy yellow slurry. At the end of
the addition, the pH is 7-8 (indicator paper). The slurry is stirred while heated
for an additional 15 min and then rapidly filtered on a 15 cm Buchner funnel.
The product thus obtained is washed thoroughly, using about 1 L of cold
water, to give a very pale yellow color in the last wash. The compound is then
pressed dry and then oven-dried for 2-3 h at 50°C. The resultant product, 9-
aminoacridine 4-hexyl resorcinolate, has a melting point of 189°-190°C. | [Brand name]
Akrinol (Schering). | [Therapeutic Function]
Antifungal, Anthelmintic |
|
| Company Name: |
CHEMICAL LAND21
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| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
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