| Identification | Back Directory | [Name]
Arteether | [CAS]
75887-54-6 | [Synonyms]
SM-22
SM-227
Areether
Artemotil
Arteether
ARPRINOCID
aArteether
NSC 665971
Unii-xgl7gfb9yi
Alpha Beta Arteether
AlphaBetaArteetherC17H28O5
dihydroqinghaosu ethyl ether
dihydroartemisinin ethyl ether
10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
10-ethoxy-1,5,9-triMethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
(3R,12aR)-3,6α,9β-Trimethyl-10β-ethoxy-3β,12α-epoxy-3,4,5,5aα,6,7,8,8aα,9,10-decahydropyrano[4,3-j]-1,2-benzodioxepin
3,12-Epoxy-12H-pyrano(4,3-J)-1,2-benzodioxepin, decahydro-10-ethoxy-3,6,9-trimethyl-, (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,12ar*))-
3,12-Epoxy-12H-pyrano(4,3-J)-1,2-benzodioxepin, 10-ethoxydecahydro-3,6,9-trimethyl-, (3S-(3alpha,5alpha,6alpha,8aalpha,9beta,10beta,12beta,12aalpha))- | [Molecular Formula]
C17H28O5 | [MDL Number]
MFCD00869355 | [MOL File]
75887-54-6.mol | [Molecular Weight]
312.4 |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
80-820C | [alpha ]
D21 +154.5° (c = 1.0 in CHCl3) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [color ]
White | [CAS DataBase Reference]
75887-54-6 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
Derivative of Artemisinin. Antimalarial | [Description]
Arteether reached the market in the Netherlands as a solution in sesame oil,
administered by i.m. injection, for the treatment of severe malaria infections in children and
adolescents. Artheether, a sesquiterpene acetal with an endoperoxide bridge, is an ether
derivative of the naturally occuring compound artemisinin, the active component of
Chinese herbal remedies. As the other structural analogs of artemisinin, such as
artesunate or artemether, it acts rapidly against Plasmodium, the parasite responsible for
the disease, during the early blood stage of its development. It also exhibits a
gametocytocidal activity against Plasmodium falciparum, reducing its potential for
transmission. Because the only controlled clinical studies had been performed in children
and adolescents, this new antimalarial drug was only approved for young patients. Further
studies in adults treated with 150 mg i.m. artemotil, once daily for three consecutive days,
indicated that the drug was efficient, rapidly acting (parasite clearance time meanly 38 h)
and well tolerated. A new promising achievement in the regression of malaria is the
combination of artemisinin derivatives with other long-lived antimalarials as mefloquine or
pyrimethamine/sulfa. | [Originator]
Central Drug Research Institute (India) | [Definition]
ChEBI: Artemotil is an artemisinin derivative. | [Brand name]
Artemotil | [storage]
Store at -20°C |
|
|