ChemicalBook--->CAS DataBase List--->77472-98-1

77472-98-1

77472-98-1 Structure

77472-98-1 Structure
IdentificationBack Directory
[Name]

Pipequaline
[CAS]

77472-98-1
[Synonyms]

45319RP
PK-8165
RP-45319
Pipequaline
CAS_77472-98-1
pipequaline PK-8165
PK-8165; PK8165; PK 8165
pipequaline HCI(PK-8165)
pipequaline.HCl(for free base)
2-phenyl-4-(2-piperidin-4-ylethyl)quinoline
2-Phenyl-4-[2-(4-piperidinyl)ethyl]quinoline
Quinoline, 2-phenyl-4-[2-(4-piperidinyl)ethyl]-
[Molecular Formula]

C22H24N2
[MDL Number]

MFCD00866983
[MOL File]

77472-98-1.mol
[Molecular Weight]

316.44
Chemical PropertiesBack Directory
[Boiling point ]

489.2±30.0 °C(Predicted)
[density ]

1.078±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
[form ]

A crystalline solid
[pka]

10.60±0.10(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Description]

Pipequaline is a partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay). In mice, pipequaline enhances the effects of diazepam , further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects. Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil .
[storage]

Store at -20°C
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