| Identification | Back Directory | [Name]
MY-5445 | [CAS]
78351-75-4 | [Synonyms]
MY-5445
MY 5445;MY5445
1-(3-CHLOROANILINO)-4-PHENYLPHTHALAZINE
1-(3-CHLOROPHENYLAMINO)-4-PHENYLPHTHALAZINE
1-(3-Chloroanilino)-4-phenylphthalazine >
N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine
N-(3-chlorophenyl)-4-phenylphthalazin-1-amine | [Molecular Formula]
C20H14ClN3 | [MDL Number]
MFCD00209838 | [MOL File]
78351-75-4.mol | [Molecular Weight]
331.8 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at RT | [solubility ]
DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml | [form ]
Yellow solid. | [color ]
White to Light yellow |
| Hazard Information | Back Directory | [Description]
MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 μM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 μM. | [Uses]
Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50=0.6μM). | [Definition]
ChEBI: N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine is a ring assembly and a member of pyridazines. | [Biological Activity]
Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC 50 = 0.5 μ M). |
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821-50328103-801 18930552037 |
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TCI Europe
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320-37350700 |
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TCI AMERICA
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800-4238616 |
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