| Identification | Back Directory | [Name]
A-7 HYDROCHLORIDE | [CAS]
79127-24-5 | [Synonyms]
A-7 HYDROCHLORIDE
1-[(10-Aminodec-1-yl)sulphamoyl]-5-chloronaphthalene
N-(10-AMINODECYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
N-(10-AMinodecyl)-5-chloro-1-naphthalenesulfonaMide Monoydrochloride
N-(10-Aminodec-1-yl)-5-chloronaphthalene-1-sulphonamide hydrochloride | [Molecular Formula]
C20H29Cl2NO2S | [MDL Number]
MFCD00269877 | [MOL File]
79127-24-5.mol | [Molecular Weight]
418.42 |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
186-188°C | [storage temp. ]
Store at RT | [solubility ]
Soluble to 50mM in DMSO | [form ]
White to off-white crystalline powder. | [color ]
Pale Yellow to Yellow | [CAS DataBase Reference]
79127-24-5 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
Naphthalenesulfonamides | [Uses]
Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. A-7 is an analog of the napthalenesulfonamide W-7 that has an acyl chain length of 10 carbons, rather than six. It is a potent cell-permeable antagonist of calmodulin that inhibits Ca2+/calmodulin cyclic nucleotide phosphodiesterase more potently than W-7 (IC50 = 3.2 and 26 μM, respectively). | [Biological Activity]
Potent calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC 50 of 3 μ M). | [storage]
Store at RT |
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