79127-24-5

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79127-24-5 Structure

Identification	Back Directory
[Name] A-7 HYDROCHLORIDE
[CAS] 79127-24-5
[Synonyms] A-7 HYDROCHLORIDE 1-[(10-Aminodec-1-yl)sulphamoyl]-5-chloronaphthalene N-(10-AMINODECYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE N-(10-AMinodecyl)-5-chloro-1-naphthalenesulfonaMide Monoydrochloride N-(10-Aminodec-1-yl)-5-chloronaphthalene-1-sulphonamide hydrochloride
[Molecular Formula] C20H29Cl2NO2S
[MDL Number] MFCD00269877
[MOL File] 79127-24-5.mol
[Molecular Weight] 418.42

Chemical Properties	Back Directory
[Appearance] White Crystalline Solid
[Melting point ] 186-188°C
[storage temp. ] Store at RT
[solubility ] Soluble to 50mM in DMSO
[form ] White to off-white crystalline powder.
[color ] Pale Yellow to Yellow
[CAS DataBase Reference] 79127-24-5

Hazard Information	Back Directory
[Chemical Properties] White Crystalline Solid
[Uses] Naphthalenesulfonamides
[Uses] Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. A-7 is an analog of the napthalenesulfonamide W-7 that has an acyl chain length of 10 carbons, rather than six. It is a potent cell-permeable antagonist of calmodulin that inhibits Ca2+/calmodulin cyclic nucleotide phosphodiesterase more potently than W-7 (IC50 = 3.2 and 26 μM, respectively).
[Biological Activity] Potent calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC 50 of 3 μ M).
[storage] Store at RT

Safety Data	Back Directory
[HS Code ] 2935909099

Spectrum Detail	Back Directory
[Spectrum Detail] A-7 HYDROCHLORIDE(79127-24-5)¹HNMR

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