ChemicalBook--->CAS DataBase List--->79548-73-5

79548-73-5

79548-73-5 Structure

79548-73-5 Structure
IdentificationBack Directory
[Name]

Pirlimycin
[CAS]

79548-73-5
[Synonyms]

Pirlimycin
Pirlimycina
Pirlimycine
Pirlimycinum
Pirlimycinum [inn-latin]
Pirlimycine [inn-french]
Pirlimycina [inn-spanish]
Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-4-ethyl-2-piperidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside
L-threo-a-D-galacto-Octopyranoside, methyl7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-4-ethyl-2-piperidinyl]carbonyl]amino]-1-thio-
L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-4-ethyl-2-piperidinyl]carbonyl]amino]-1-thio-
Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-4-ethyl-2-piperidinyl]carbonyl]amino]-1-thio-L-threo-alpha-D-galactooctopyranoside
L-Threo-alpha-galacto-octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-((((2S,4R)-4-ethyl-2-piperidinyl)carbonyl)amino)-1-thio-
L-Threo-alpha-galacto-octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(((4-ethyl-2-piperidinyl)carbonyl)amino)-1-thio-, (2S-cis)-
(2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-4-ethylpiperidine-2-carboxamide
[Molecular Formula]

C17H31ClN2O5S
[MDL Number]

MFCD00864968
[MOL File]

79548-73-5.mol
[Molecular Weight]

410.96
Chemical PropertiesBack Directory
[Boiling point ]

643.9±55.0 °C(Predicted)
[density ]

1.31
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
[form ]

solid
[pka]

12.88±0.70(Predicted)
[Stability:]

Hygroscopic
Hazard InformationBack Directory
[Uses]

Pirlimycin is a semi-synthetic lincosamide prepared from clindamycin by hydrolysing the propyl N-methylproline and re-annealing a 4-ethylpipecolic acid. Pirlimycin is more hydrophobic than clindamycin and is more potent against a number of important pathogens. Like other members of the lincosamide family, pirlimycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Pirlimycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Pirlimycin has been less extensively researched than the older lincosamides.
[Biological Activity]

pirlimycin, a lincosamide antibiotic, is effective against gram-positive bacteria, including staphylococcus, bacteroides, streptococcus, and plasmodium. it functions via inhibiting protein synthesis in bacteria by inducing premature dissociation of the peptidyl-trna from the ribosome.
[Veterinary Drugs and Treatments]

Pirlimycin mastitis tubes are indicated for the treatment of clinical and subclinical mastitis caused by susceptible organisms in lactating dairy cattle.
[in vitro]

pirlimycin showed activity against helicobacter pylori with a minimal inhibitory concentration [mic] 50 of 4 μg/ml and an mic90 of 64 μg/ml [1].
[in vivo]

cows were treated with 50 mg of pirlimycin via two intramammary infusions per quarter at a 24-hour interval (2-day) for 2, 5, or 8 days. pirlimycin showed antibiotic therapy against environmental streptococcus spp and staphylococcus aureus intramammary individual and combined infections [1]. specifically, pirlimycin cured environmental streptococcus spp infections in 66.7% (14/21), 85% (17/20), 100% (14/14) in the 2-day group, 5-day group and 8-day group, respectively. s. aureus infections were cured by the treatment of pirlimycin in 13.3% (2/15), 31.3% (5/16), 83.3% (5/6) in the 2-day group, 5-day group and 8-day group, respectively. furthermore, s. aureus, s. dysgalactiae subsp dysgalactiae, and enterococcus spp intramammary infections were eliminated by the extended treatment of pirlimycin in 8-day group [2].
[References]

[1]. westblom, t., midkiff, b., & czinn, s. in vitro susceptibility ofhelicobacter pylori to trospectomycin, pirlimycin (u-57930e), mirincamycin (u-24729a) and n-demethyl clindamycin (u-26767a). european journal of clinical microbiology & infectious diseases. 1993; 12(7): 560-562.
[2]. b. e. gillespie, h. moorehead, p. lunn, h. h. dowlen, d. l. johnson, k. c. lamar, m. j. lewis, s. j. ivey, j. w. hallberg, s. t. chester, and s. p. oliver. efficacy of extended pirlimycin hydrochloride therapy for treatment of environmental streptococcus spp and staphylococcus aureus intramammary infections in lactating dairy cows. veterinary therapeutics. 2002; 3(4): 373-80.
79548-73-5 suppliers list
Company Name: Shenzhen Nexconn Pharmatechs Ltd
Tel: +86-755-89396905 +86-15013857715 , +86-15013857715
Website: https://www.chemicalbook.com/ShowSupplierProductsList31188/0.htm
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Website: www.afinechem.com/index.html
Company Name: BOC Sciences
Tel: 16314854226; +16314854226 , +16314854226
Website: https://www.bocsci.com/
Company Name: Hebei Duling International Trade Co. LTD
Tel: +8617333973358 , +8617333973358
Website: www.hebeiduling.cn/
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207 , +8617767106207
Website: https://www.molcore.com/
Company Name: Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Tel: +86-19164747840 +86-13119157289 , +86-13119157289
Website: www.cuikangmed.com/
Company Name: Nanjing Sunlida Biological Technology Co., Ltd.  
Tel: 025-57798810
Website: http://www.sunlidabio.com
Company Name: Hangzhou J&H Chemical Co., Ltd.  
Tel: +86-571-87396432
Website: www.jhechem.com
Company Name: Alta Scientific Co., Ltd.  
Tel: 022-6537-8550 15522853686
Website: http://www.altascientific.cn
Company Name: Shanghai Synchem Pharma Co., ltd  
Tel: 21-619849051-1 18521059765
Website: www.synchem-pharma.com
Company Name: Raw material medicin reagent co.,Ltd  
Tel:
Website: http://www.njromanme.com
Company Name: Lynnchem  
Tel: 86-(0)29-85992781 17792393971
Website: http://www.lynnchem.com/
Company Name: Novachemistry  
Tel: 44-20819178-90 02081917890
Website: https://www.novachemistry.com/
Company Name: Jinan Yaoyan Pharmaceutical Co., Ltd.  
Tel:
Website: www.chemicalbook.com/ShowSupplierProductsList30574/0.htm
Company Name: Shenzhen Polymeri Biochemical Technology Co., Ltd.  
Tel: +86-400-002-6226 13028896684
Website: https://www.rrkchem.com
Company Name: Taizhou Crene Biotechnology Co. Ltd.  
Tel: 0576-88813233 13396860566
Website: http://www.pharm-intermediates.com
Company Name: Nanjing Meihao Pharmaceutical Technology Co., Ltd.  
Tel: meitaochem@126.com
Website: www.chemicalbook.com/ShowSupplierProductsList31244/0.htm
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Website: www.chemegen.com
Tags:79548-73-5 Related Product Information
162011-90-7