| Identification | Back Directory | [Name]
20-HETE | [CAS]
79551-86-3 | [Synonyms]
20-HETE
20-HYDROXYARACHIDONIC ACID
20-Hydroxyarachlidonic acid
omega-Hydroxyarachidonic acid
20-HETE Lipid Maps MS Standard
20-Hydroxyeicosatetraenoic acid
20-HETE, 20-Hydroxyarachidonic acid
20-hydroxy-5,8,11,14-eicosatetraenoic acid
20-Hydroxyeicosa-5Z,8Z,11Z,14Z-tetraenoic acid
20-HYDROXY-(5Z,8Z,11Z,14Z)-EICOSATETRAENOIC ACID
(5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid
5,8,11,14-Eicosatetraenoic acid, 20-hydroxy-, (5Z,8Z,11Z,14Z)- | [Molecular Formula]
C20H32O3 | [MDL Number]
MFCD00171542 | [MOL File]
79551-86-3.mol | [Molecular Weight]
320.47 |
| Chemical Properties | Back Directory | [Boiling point ]
482.0±33.0 °C(Predicted) | [density ]
0.985±0.06 g/cm3(Predicted) | [Fp ]
14℃ | [storage temp. ]
-20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml | [form ]
Powder | [pka]
4.75±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
20-HETE is a cytochrome P450 (CYP450) metabolite that may play an autacoid role in cerebral and renal vasculature. | [Definition]
ChEBI: A HETE that consists of arachidonic acid bearing a hydroxy substituent at position 20. | [Biochem/physiol Actions]
20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid (20-HETE) is an arachidonic acid metabolite via cytochrome P4504A, that is an activator of the Ras/MAP (microtubule-associated protein) pathway. 20-HETE acid is a predominant arachidonic acid present in the kidney. It is involved in the regulation of sodium, potassium and chloride transport in the renal tubules. 20-HETE is often excreted in urine in the form of glucuronide conjugate and sometimes as free acids. Increased urine 20-HETE is observed during pregnancy in rats. |
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