| Chemical Properties | Back Directory | [Occurrence]
The root bark of Dulacia guianensis yields manicolines A and B which have been separated
by chromatographic methods. This component forms pale yellow crystals from AcOEt and
is dextrorotatory with a specific rotation of [α]D +69° (c 0.9, CHC13 + 10% EtOH). Manicoline A is not cytotoxic for chick embryo fibroblasts up to doses of 5 Il. g/mL
and does not inhibit cell transformation induced by Rous sarcoma virus. |
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