| Identification | Back Directory | [Name]
1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate (aMMoniuM salt) | [CAS]
799279-67-7 | [Synonyms]
C18 LPA
1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate (aMMoniuM salt)
1-O-OCTADECYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHATE (AMMONIUM SALT);C18 LPA | [Molecular Formula]
C21H48NO6P | [MDL Number]
MFCD22416844 | [MOL File]
799279-67-7.mol | [Molecular Weight]
441.59 |
| Hazard Information | Back Directory | [Uses]
Glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states. | [General Description]
Lysophosphatidic?acid (LPA) is a class of phospholipids, which is water-soluble. It has a glycerol backbone attached?via?a phosphate group, an aliphatic chain and a hydroxyl group.?The aliphatic chain is linked to either?sn-1 or?sn-2 position and the phosphate group is connected to the?sn-3 position. The hydroxyl group is linked to the remaining?sn-1 or?sn-2?position. | [Biochem/physiol Actions]
Lysophosphatidic?acid (LPA) is a signaling molecule and alters various cellular responses through G protein-coupled receptors (GPCRs). It stimulates smooth muscle contraction, cytoskeleton rearrangement and chemotaxis. LPA is also involved in inducing neurotransmitter release, cell proliferation, platelet aggregation and Ca2+ mobilization. Increased levels of LPA in human plasma leads to ovarian cancer and atherosclerosis. LPA acts as a potential biomarker for ovarian cancer. |
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