| Identification | Back Directory | [Name]
tilivalline | [CAS]
80279-24-9 | [Synonyms]
tilivalline
(6S,6aS)-4-hydroxy-6-(1H-indol-3-yl)-5,6,6a,7,8,9-hexahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one
5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 1,2,3,10,11,11a-hexahydro-9-hydroxy-11-(1H-indol-3-yl)-, (11S,11aS)- | [Molecular Formula]
C20H19N3O2 | [MOL File]
80279-24-9.mol | [Molecular Weight]
333.38 |
| Chemical Properties | Back Directory | [Melting point ]
>215°C (dec.) | [storage temp. ]
Hygroscopic, Refrigerator, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [color ]
Pale Beige to Light Brown | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Tilivalline, is a metabolite from Klebsiella oxytoca. Tilivalline, is shown to be cytotoxin, and the key event causing Antibiotic-Associated Hemorrhagic Colitis. | [Definition]
ChEBI:Tilivalline is a pyrrolobenzodiazepine that is (11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine substituted by an oxo group at position 5, by a hydroxy group at position 9, and by a 1H-indol-3-yl group at position 11S. It is a natural product discovered in Klebsiella oxytoca which is the causative toxin in antibiotic associated hemorrhagic colitis. It exhibits a microtubule-stabilizing activity that leads to mitotic arrest in the host cells. It has a role as a microtubule-stabilising agent, a toxin and a bacterial metabolite. It is a pyrrolobenzodiazepine, a member of phenols, an indole alkaloid and a member of indoles. |
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