| Identification | Back Directory | [Name]
DifluoroiodoMethyl phenyl sulfone | [CAS]
802919-90-0 | [Synonyms]
DifluoroiodoMethyl phenyl sulfone
(difluoroiodomethylsulfonyl)benzene
Benzene, [(difluoroiodomethyl)sulfonyl]- | [Molecular Formula]
C7H5F2IO2S | [MDL Number]
MFCD28100936 | [MOL File]
802919-90-0.mol | [Molecular Weight]
318.08 |
| Hazard Information | Back Directory | [Description]
A visible light-catalysed direct and regioselective (phenylsulfonyl) difluoromethylation of imidazo[1,2-A]pyridines and benzo[d]-imidazo[2,1-b]thiazoles was carried out by DifluoroiodoMethyl phenyl sulfone under mild conditions. This synthetic methodology enables the introduction of a CF2SO2Ph group in an efficient and regioselective reaction through C-H bond functionalization with a broad substrate scope in good to excellent yields. | [Uses]
Iododifluoromethyl
phenyl sulfone can be used for the difluoromethylation of alkenes and alkynes initiated by
triethylborane/air or arenediazonium salt/titanium chloride in moderate to good yields. | [Reactions]
(1) Difluoromethylation of terminal alkenes and alkynes.
| [References]
[1] GUO-JIE YIN; W. F; Mei Zhu. Visible-light mediated regioselective (phenylsulfonyl)difluoromethylation of fused imidazoles with iododifluoromethyl phenyl sulfone[J]. Heterocyclic Communications, 2017. DOI:10.1515/hc-2017-0101.
[2] YA LI. Radical (Phenylsulfonyl)difluoromethylation with Iododifluoromethyl Phenyl Sulfone[J]. The Journal of Organic Chemistry, 2007. DOI:10.1021/jo070618s.
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