| Identification | Back Directory | [Name]
Benzoic acid, 3,4,5-trimethoxy-2-[[2-[(3-pyridinylcarbonyl)amino]benzoyl]amino]-, methyl ester | [CAS]
81469-77-4 | [Synonyms]
Preterramide C
Benzoic acid, 3,4,5-trimethoxy-2-[[2-[(3-pyridinylcarbonyl)amino]benzoyl]amino]-, methyl ester | [Molecular Formula]
C24H23N3O7 | [MDL Number]
MFCD33021347 | [MOL File]
81469-77-4.mol | [Molecular Weight]
465.46 |
| Hazard Information | Back Directory | [Biological Activity]
Preterramide C is a fungal metabolite that has been found in A. terreus.1 It is active against S. aureus (MIC = 52.4 μM) but not E. aerogenes, P. aeruginosa, or C. albicans (MICs = >100 μM for all).2 Preterramide C inhibits the growth of L5178Y mouse lymphoma cells with an IC50 value of 0.1 μg/ml.3 It also inhibits nitric oxide (NO) production induced by LPS in RAW 264.7 cells (IC50 = 5.48 μM). | [References]
1.He, F., Bao, J., Zhang, X.-Y., et al.Asperterrestide A, a cytotoxic cyclic tetrapeptide from the marine-derived fungus Aspergillus terreus SCSGAF0162J. Nat. Prod.76(6)1182-1186(2013)
2.Wang, Y., Zheng, J., Liu, P., et al.Three new compounds from Aspergillus terreus PT06-2 grown in a high salt mediumMar. Drugs9(8)1368-1378(2011)
3.Zhou, Y., Mandi, A., Debbab, A., et al.New austalides from the sponge-associated fungus Aspergillus sp.Eur. J. Org. Chem.306009-6019(2011)
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