| Identification | Back Directory | [Name]
MPEG4-CH2CH2COOH | [CAS]
81836-43-3 | [Synonyms]
m-PEG5-COOH
m-PEG5-acid
Methyl-PEG4-acid
MPEG4-CH2CH2COOH
mPEG4-propionic acid
4,7,10,13,16-Pentaoxaheptadecanoic acid
2,5,8,11,14-pentaoxaheptadecan-17-oic acid | [Molecular Formula]
C12H24O7 | [MDL Number]
MFCD20926398 | [MOL File]
81836-43-3.mol | [Molecular Weight]
280.31 |
| Chemical Properties | Back Directory | [Boiling point ]
393.0±37.0 °C(Predicted) | [density ]
1.107±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Description]
m-PEG5-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. | [References]
[1] Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67. DOI:10.3762/bjoc.11.74 |
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