| Identification | Back Directory | [Name]
AMN082 DIHYDROCHLORIDE | [CAS]
83027-13-8 | [Synonyms]
AMN 082
AMN082 free base
AMN 082 dihydrochlor
AMN082 DIHYDROCHLORIDE
N,N'-bis(diphenylMethyl)ethylenediaMine
N,N'-DIBENZHYDRYLETHANE-1,2-DIAMINE DIHYDROCHLORIDE
N,N'-Bis(diphenylmethyl)-1,2-ethandiamine dihydrochloride
N,N'-BIS(DIPHENYLMETHYL)-1,2-ETHANEDIAMINE DIHYDROCHLORIDE | [Molecular Formula]
C28H28N2 | [MDL Number]
MFCD08702723 | [MOL File]
83027-13-8.mol | [Molecular Weight]
392.54 |
| Chemical Properties | Back Directory | [Melting point ]
105.5 °C | [Boiling point ]
533.7±45.0 °C(Predicted) | [density ]
1.086±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [solubility ]
DMSO : 12.5 mg/mL (31.84 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
8.38±0.29(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AMN082 dihydrochloride is a selective agonist at mGluR-7. | [Definition]
ChEBI: N,N'-bis(diphenylmethyl)ethane-1,2-diamine is a diamine that is ethane-1,2-diamine in which both amino groups are substituted by diphenylmethyl groups. It is an allosteric agonist of the metabotropic glutamate receptor 7 (mGluR7). It has a role as a metabotropic glutamate receptor agonist and a neuroprotective agent. It is a diarylmethane, a secondary amino compound, a diamine and a member of benzenes. It is a conjugate base of a N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+). | [Biological Activity]
The first selective mGlu 7 agonist. Potently inhibits cAMP accumulation and stimulates GTP γ S binding in recombinant cells and on membranes expressing mGlu 7 (EC 50 = 64-290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μ M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats. |
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