| Identification | Back Directory | [Name]
1-Propanol, 2-methoxy-3-(octadecyloxy)-, (2S)- | [CAS]
83167-59-3 | [Synonyms]
2(S)-methoxy-3-(octadecyloxy)-1-propanol
1-Propanol, 2-methoxy-3-(octadecyloxy)-, (2S)- | [Molecular Formula]
C22H46O3 | [MOL File]
83167-59-3.mol | [Molecular Weight]
358.6 |
| Hazard Information | Back Directory | [Description]
1-O-Octadecyl-2-O-methyl-sn-glycerol is a metabolite of a phosphotidylinositol ether lipid analog (PIA). PIAs are known to target the pleckstrin homology domain of the serine/threonine kinase Akt and to induce apoptosis in cancer cell lines with high levels of endogenous Akt activity.1,2 | [References]
1. Castillo, S.S., Brognard, J., Petukhov, P.A., et al. Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues Cancer Res. 64(8),2782-2792(2004).
2. Memmott, R.M., Gills, J.J., Hollingshead, M., et al. Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non-small cell lung cancer cells Cancer Res. 68(2),580-588(2008). |
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